A recent audit of 1,006 inflammatory bowel disease (IBD) patients recently switched from one biologic/JAK therapy to another found that TNFs are largely preferred for first-line treatment, though at second line, close to half of surveyed gastroenterologists (n=191) chose an alternate mechanism of action (MOA) in Crohn’s disease and about 40% preferred an alternate MOA in ulcerative colitis (UC). View complimentary data highlights.
Insights from the Mavenclad prelaunch section in the most recent quarterly report suggest a later line role for Mavenclad among DMT-refractory RMS patients with aggressive disease activity. Vumerity, on the other hand, will most likely be used earlier in the treatment algorithm in Tecfidera candidates where avoidance of tolerability issues is key. View complimentary data highlights from the full report below.
We analyzed the charts of 1,006 US psoriasis patients who were switched from one biologic/small molecule to a different brand in the past three months. Here we highlight one patient record from Spherix's RealWorld Dynamix: Biologic/Otezla Switching in Psoriasis (US) audit, detailing the patient's journey from diagnosis to their current switched treatment.
Efficacy is the most common trigger for a switch, though the switch patterns differ dramatically depending on whether it was a primary vs. secondary efficacy issue, with other factors, such as patient and payer influence, also playing a role. Reasons for new brand choice also vary between classes of treatment. View complimentary data highlights full 2018 report below.
In a recent patient chart audit, Genentech’s Ocrevus was a common alternative or “back up” disease-modifying therapy (DMT) for secondary progressive multiple sclerosis (SPMS) patients that went on to be treated with a different DMT.
According to the recent audit, ICER's recognition of progressive disease as "active" or "not active" is a clinically relevant distinction due to the significant differences in patient demographics, disability progression, and treatment patterns between the active and not active SPMS subgroups.