About 15 disease-modifying therapies (DMTs) are available to treat MS these days. So, choosing which to use can be daunting. I’ve been treated with four DMTs since I was first prescribed Avonex (interferon beta-1a) back in 1996. Each time I’ve switched treatments, my neurologist has suggested a number of DMTs she thought would be best for me. But she left the final decision in my hands.
From: Lupus News Today By: Iqra Mumal Patients participating in Phase 3 clinical trials testing new therapies for systemic lupus erythematosus (SLE) are not necessarily representative of real-world patient populations, according to a new report. Even if the therapies being investigated reach the market, real-world experiences may differ significantly from trial results because many lupus patients are not eligible to participate in studies due to exclusion criteria, the report says....(read more).
From: MedPage Today By: Salynn Boyles, Contributing Writer, MedPAge Today NASHVILLE -- Ocrelizumab (Ocrevus), the first and only FDA-approved disease-modifying therapy (DMT) to treat primary progressive multiple sclerosis (PPMS), has lived up to its hype, according to the CEO of the Consortium of Multiple Sclerosis Centers (CMSC). "Ocrelizumab has really changed the landscape for patients who haven't had many therapeutic options in the past. I do think that, so far at least, it has lived up to the hype," June Halper, MSN, told MedPage Today. Ocrelizumab is a humanized, monoclonal antibody that targets CD20+ B cells. FDA approval in 2017 [...]
From: MedPage Today Byy: Ed Susman, Contribution Writer, MedPAge Today LAS VEGAS -- TNF inhibitors remain the predominant treatment in Crohn's disease, but ustekinumab (Stelara) has been quickly adopted by clinicians, accounting for about one in five recently switched patients, researchers reported here. The agent received FDA approval in 2016 for the treatment of moderately to severely active Crohn's disease in adults who have failed or were intolerant to treatment with immunomodulators or corticosteroids but never failed treatment with a TNF blocker, or who failed or were intolerant to treatment with one or more TNF blockers...(read more).