RealTime Dynamix™: Multiple Sclerosis EU 2017-12-04T21:18:43+00:00

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RealTime Dynamix: Multiple Sclerosis EU (bi-annual)

The EU multiple sclerosis (MS) market is more dynamic and complex than ever with several clinically distinct disease-modifying therapies (DMTs) cur-rently available and an active pipeline, including a potential game-changer entry in 2017, in the form of Roche’s Ocrevus (ocrelizumab), for primary progressive MS. In addition, building on the first generic DMT launch in 2016, the availability of oral generics over the next few years will result in a major future shift in the landscape in the face of increasing payer pressure.

RealTime Dynamix™: Multiple Sclerosis (EU) provides a twice-yearly analysis of key performance metrics, focusing on brand gains and losses, industry contact rates, familiarity and adoption rates of recently launched products and awareness of products in development. This ongoing, independent insights series allows marketing professionals to keep abreast of and quickly react to market changes by providing critical information that will support their commercial strategies in the MS space.

Biannually, ~250 EU neurologists practicing in France, Germany, Italy, Spain, and the UK provide their responses to an online survey. Neurologists meet screening criteria including time in practice, percent of professional time spent in clinical practice (vs. teaching or research), and minimum number of MS patients. Surveys are programmed in the local language.

This bi-annual report has been fielded since 2016.

Learn more about RealTime Dynamix™ reports here.

  • How is the current and near-term landscape for the MS market evolving? How does this differ by country?
  • What are the critical opportunities and barriers to growth for each brand and class?
  • Which DMTs will feel the greatest impact by the launch of Ocrevus?
  • How are the three oral agents delivering on the key attributes and on typical patient types?
  • How are the platform injectables being positioned to optimize first-line use and time on drug? To what degree do neurologists have strong preferences for specific brands?
  • With fewer opportunities for personal interactions, what are the best channels for industries to share product information with neurologists?
  • What are the neurologists’ attitudes towards Lemtrada, Tysabri, and Ocrevus, the high efficacy infusion DMTs? Where does Zinbryta fit in with the monoclonal antibodies versus the injectable DMTs?
  • How is generic glatiramer acetate faring in the EU markets where available? To what extent is use driven by neurologist choice versus market access pressure?
  • How are PML concerns affecting Tysabri, Tecfidera, and Gilenya?
  • How often are patients requesting specific DMT brands?
  • What are the neurologists’ perceptions of late-stage pipeline assets and how do they anticipate incorporating these products into their MS treatment?
Commercial Products
Bayer (Betaferon), Biogen (Avonex, Plegridy, Tecfidera, Tysabri, Zinbryta), Merck KGaA (Rebif), Sanofi (Aubagio, Lemtrada), Novartis (Gilenya, Extavia), Roche (Ocrevus*, Rituxan), Teva (Copaxone), multiple companies (Synthon’s glatiramer acetate*)
*May still be pipeline in certain EU markets at time of fielding

Pipeline Agents
AB Science (masitinib), Active Biotech/Teva (laquinimod), Biogen (anti-LINGO), Celgene/Receptos (ozanimod), J&J/Acteli (ponesimod), MedDay (MD1003), Merck KGaA (cladribine), Novartis (siponimod, ofatumumab)

Download Report Overview (PDF)


Early Adopters in Germany and the United Kingdom Are Prescribing Merck KGaA’s Mavenclad as First-Line Induction Therapy for the Treatment of Multiple Sclerosisk – November 21, 2017

FDA Approval of Mylan’s Glatiramer Acetate Will Turn the Payer Pressure On for Teva’s Copaxone and Sandoz’s Glatopa – October 4, 2017