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RealTime Dynamix: Multiple Sclerosis Canada (semiannual)

The multiple sclerosis (MS) market in Canada is more dynamic and complex than ever with several clinically distinct disease-modifying therapies (DMTs) currently available, including the recent launch of Roche’s Ocrevus, for early primary progressive MS (PPMS) and relapsing forms of MS (RMS), EMD Seronos’s Mavenclad, an oral induction therapy for RMS, and generic glatiramer acetate agents. An active late-stage DMT pipeline holds the promise of a 2019 launch of Novartis’ Mayzent with a first-to-market secondary progressive MS (SPMS) label. Evolving practice guidelines recommend early treatment with high efficacy DMTs in highly active MS patients although neurologists’ beliefs and prescribing patterns do not appear to always be in sync.

RealTime Dynamix™: Multiple Sclerosis (Canada) provides a twice-yearly analysis of key performance metrics, focusing on brand gains and losses, industry contact rates, familiarity and adoption rates of recently launched products, and awareness of products in development. Product perceptions, disease awareness and attitudes, practice management and other topics are rotated throughout the year to provide an ongoing probe of the crucial drivers of change. This ongoing, independent insights series allows marketing professionals to keep abreast of and quickly react to market changes by providing critical information that will support their commercial strategies in the MS space.

Biannually, ~50 Canadian neurologists practicing in, but not limited to, Quebec, Ontario, and British Columbia provide their responses to an online survey. Participating neurologists meet screening criteria including time in practice, percent of professional time spent in clinical practice (vs. teaching or research), and minimum number of MS patients.

This bi-annual report will begin fielding in Q2 2019.

Learn more about RealTime Dynamix™ reports here.

  • How is the current and near-term landscape for the MS market evolving? How does this differ by province?
  • What are the critical opportunities and barriers to growth for each brand and class?
  • How is the treatment algorithm changing with increasing oral DMT experience and expanding options within the monoclonal antibody DMT class?
  • How are newcomers, Mavenclad and Ocrevus, impacting the RMS market? With continued market penetration, where are neurologists using Ocrevus in the RMS treatment algorithm? Is Mavenclad perceived and used as a first-line RMS option? Has Ocrevus grown the PPMS market segment?
  • How is the availability of generic glatiramer acetate impacting the market? To what extent is use driven by neurologist choice versus payer mandate?
  • To what degree do neurologists have strong preferences for specific brands within the DMT classes? How are the DMTs delivering on the key attributes and on typical patient types?
  • With fewer opportunities for personal interactions, what the best channels for industry to share product information with neurologists?
  • What are neurologists’ perceptions of late-stage pipeline assets and how do they anticipate incorporating these products into their MS treatment?
  • To what degree will the availability of Mayzent expand the SPMS segments or increase the switch rate during SPMS transition? What treatment patterns will differ between active versus not active SPMS patients?
Commercial Products
Bayer (Betaseron), Biogen (Avonex, Plegridy, Tecfidera, Tysabri), EMD Serono (Mavenclad, Rebif), Novartis (Gilenya, Extavia), Pendopharm (Glatect), Roche (Ocrevus, Rituxan), Sanofi (Aubagio, Lemtrada), Teva (Copaxone)

Pipeline Agents
AB Science (masitinib), Biogen [opicinumab, Vumerity* (with Alkermes)], Celgene (ozanimod), J&J/Actelion (ponesimod), MedDay (MD-1003), MediciNova (ibudilast), Novartis (Mayzent*, ofatumumab), TG Therapeutics (ublituximab)

*Could move to commercial products based upon regulatory outcomes


Amid the COVID-19 Pandemic, Neurologists in Canada Report Pulling Back from EMD Serono’s Mavenclad and Sanofi Genzyme’s Lemtrada, While Roche’s Ocrevus Stalls, According to Spherix Global Insights – May 27, 2020

Opportunity for EMD Serono’s Mavenclad is Growing in the Relapsing-Remitting Multiple Sclerosis Segment of the Canada Market, Although Increasingly Deferred Treatment Algorithm Positioning Is a Threat That Could Benefit Roche’s Ocrevus and Novartis’ Gilenya – November 19, 2019