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RealTime Dynamix: Atopic Dermatitis US (quarterly)

Atopic dermatitis (AD), the most common form of eczema affecting 5 to 20% of the worldwide population, is a chronic inflammatory disease often presenting as a skin rash. Moderate-to-severe AD is characterized by rashes often covering much of the body and can include intense itching and dryness, crusting, redness, and oozing, which can be debilitating. Until now, there have been few options to treat more severe forms of AD, but with the approval of dupilumab, an IL-4/13 blocker, dermatologists have their first FDA approved biologic option to battle this disease. A host of other biologics and novel small molecules are in the pipeline and, as a result, the treatment paradigm for AD is expected to undergo a monumental shift over the next two to three years.

The RealTime Dynamix™: Atopic Dermatitis (US) report series provides a detailed and timely look at current and future trends in the AD market, and the effects of the future shifting landscape. The quarterly releases allow for close monitoring and trending of key performance metrics. In addition to the fixed trended measures, the report also includes variable content addressing key current issues updated quarterly. The rapid field-to-insight turnaround time, highly relevant content, and unparalleled knowledge of the dermatology market make this an essential tool for companies competing in the space, as well as those with near-term plans to enter it.

The report is based on an online survey of ~100 US dermatologists and is fielded on a quarterly basis. Respondents are recruited from the Spherix Network, a proprietary group of dermatologists in clinical practice meeting quality screening criteria. Our relationship with this network leads to more engaged respondents resulting in higher quality output.

This quarterly report has been fielded since Q1 2016.

Learn more about RealTime Dynamix™ reports here.

  • What are the adoption and share trends for Pfizer’s Eucrisa since the launch and what products are losing to this new entrant?
  • What are the adoption and share trends for Dupixent since its early 2017 launch, and how is the first AD biologic impacting the market?
  • What promotional tactics are being employed during launches?
  • What are the trial, adoption, and persistency rates?
  • How prominent is off-label prescribing of biologic or small molecule agents in moderate-to-severe AD and how have they shifted post-approval of Dupixent?
  • What are key barriers to Eucrisa and Dupixent adoption?
  • What role are payers and patients playing in the uptake of these two new agents?
  • Which molecules in development for the treatment of AD will have the greatest potential?
Commercial Products
Sanofi-Regeneron (Dupixent)

Classes: topical steroids, topical CNIs, conventional systemics, oral steroids, off-label biologics and small molecules

Pipeline Agents
AbbVie (upadacitinib), Amgen (tezepelumab), AnaptysBIO (etokimab), Asana BioSciences (ASN002), Dermata (DMT210), Dermira (lebrikizumab), Eli Lilly (baricitinib), Galderma (nemolizumab), Incyte (ruxolitinib), LEO Pharma (delgocitinib, tralokinumab), Novartis (MOR106, ZPL389), Pfizer (abrocitinib), Vanda (tradipitant)


Dermatologists Are Extremely Satisfied with Sanofi/Regeneron’s Dupixent in Atopic Dermatitis, Though the Brand Leaves Certain Patient Segments Untapped: Will JAK Inhibitors Be the One to Fill the Gap?
– August 20, 2020

US Dermatologists Anticipate the Future of Atopic Dermatitis to Mirror that of the Over-Crowded Psoriasis Market
– March 17, 2020